Figure 8.

Histopathological profiles of the spleen in the intact control ((a), (b)), CIA control ((c), (d)), Enbrel group ((e), (f)), and platycodin D-treated groups; 200 mg/kg ((g), (h)), 100 mg/kg ((i), (j)), and 50 mg/kg ((k), (l)). Marked enlargement of the spleen, related to hyperplasia of lymphoid cells in the white pulp, was detected in the CIA control mice. However, these histopathological changes decreased dramatically after treatment with Enbrel and all three doses of platycodin D. Arrow indicates the total spleen thickness. Doted arrow indicates white pulp. All were stained with H&E. Scale bars = 160 μm.