Table 1.

Changes of left hind paw and secondary lymphatic organs detected after treatment of Enbrel and three different dosages of platycodin D in CIA mice.

Groups	Paw weights		Spleen weights		Left popliteal lymph nodes weights
	Absolute	Relative	Absolute	Relative	Absolute	Relative
Controls
Intact	0.133 ± 0.008	0.667 ± 0.022	0.047 ± 0.008	0.236 ± 0.028	0.003 ± 0.002	0.013 ± 0.009
CIA	0.202 ± 0.027a	1.195 ± 0.188a	0.101 ± 0.009a	0.599 ± 0.075a	0.015 ± 0.004a	0.088 ± 0.025a
Reference
Enbrel	0.136 ± 0.004c	0.665 ± 0.037c	0.062 ± 0.004ac	0.302 ± 0.022ac	0.005 ± 0.004c	0.025 ± 0.020c
Platycodin D
200 mg/kg	0.128 ± 0.011c	0.688 ± 0.121c	0.055 ± 0.003bc	0.291 ± 0.022ac	0.007 ± 0.003bc	0.036 ± 0.017bc
100 mg/kg	0.140 ± 0.018c	0.763 ± 0.144c	0.062 ± 0.008ac	0.335 ± 0.047ac	0.008 ± 0.003ac	0.041 ± 0.015ac
50 mg/kg	0.154 ± 0.029d	0.902 ± 0.243bd	0.074 ± 0.019ad	0.435 ± 0.141ad	0.011 ± 0.003ac	0.061 ± 0.017ac

Values are expressed as mean ± SD, g (absolute weight), or % (relative weights versus body weights at sacrifice) of eight mice. ^a P < 0.01 as compared with intact control by LSD test, ^b P < 0.01 and ^c P < 0.05 as compared with CIA control by LSD test, and ^d P < 0.01 as compared with intact control by MW test.