Table 1.
Marker | Author | Sensitivity/ specificity | Method | Medication | Applicability |
---|---|---|---|---|---|
Carbonic anhydrase IX | Bui et al. 2003 | NC | Immunohistoc hemistry, Rt-PCR, ELISA | None | Prognostic factor |
VEGFR3 polymorphism: rs307826, rs307821 | Garcia-Donas, et al. 2011 | NC | Single nucleotide polymorphism | Sunitinib | Predictive factor |
IL-8 2767TT, HIF1α 1790AG phenotypes | Xu et al. 2011 | NC | Sequencing | Pazopanib | Predictive factor |
CD45dimCD34+VE GFR2+7AAD- | Farace et al. 2011 | NC | Flow cytometry | Sunitinib | Clinical efficacy |
CD146+ | Gruenwald et al. 2010 | NC | Flow cytometry | Sunitinib | Clinical efficacy |
VHL mutation/methylation | Rini et al. 2006 | NC | PCR, DNA sequencing | Interferon-α + Bevacizumab | Predictive factor |
VEGFR-3 |
Rini et al. 2008 Escudier et al, 2009 DePrimo et al, 2007 |
NC | ELISA ELISA |
Sunitinib Sorafenib Sunitinib |
Clinical efficacy Prognostic factor |
VEGF-C | Rini et al. 2008 | NC | ELISA | Sunitinib | Clinical efficacy |
VEGFR-2 |
Escudier et al, 2009 DePrimo et al, 2007 |
NC | ELISA ELISA |
Sunitinib Sunitinib |
Prognostic factor |
VEGF |
Escudier et al, 2009 Pena et al, 2010 Porta et al, 2010 DePrimo et al, 2007 |
NC | ELISA ELISA ELISA ELISA |
Sunitinib Sorafenib Sunitinib Sunitinib |
Prognostic factor Prognostic/Predictive factor Prognostic factors |
SAA | Vermaat et al, 2012 | 59% / 77% | ELISA | Sunitinib Sorafenib |
Prognostic factor |
NGAL | Perrin et al, 2011 | NC | ELISA | Sunitinib | Prognostic factor |
ESR | Zhang et al, 2011 | NC | Westegren | Sorafenib | Predictive factor |
MMP-9 | Perez-Garcia et al, 2009 | 55.6% / 75% | ELISA | Sunitinib | Prognostic factor |
TNFα | Perez-Garcia et al, 2009 | 88% / 75% | ELISA | Sunitinib | Prognostic factor |
Hepatocyte growth factor, IL-8, OPN, TIMP-1) | Tran et al, 2012 | NC | ELISA | Pazopanib | Prognostic factor |
OPN, VEGF, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), ColIV and sVEGFR2 | Zurita et al, 2012 | NC | Multiplex bead array, ELISA | Sorafenib | Predictive factor |
LDH | Armstronge et al, 2012 | NC | Temsirolimus | Predictive factor | |
Cholesterol | Lee et al, 2012 | NC | Temsirolimus | Predictive factor |