(c) Efficacy of tocilizumab in protection of radiographic progression of joints

Study	Radiographic assessment	Week at evaluation	Treatment arms	Proportion without progression TSS ≦ 0	Change in score (95% CI)
					Total score	Erosion score	JSN score
SAMURAI	van der Heijde-modified Sharp score	52 W	TCZ (8 mg/kg)	56**	2.3**, (1.5–3.2)	0.9***, (0.3–1.4)	1.5*, (0.9–2.1)
			DMARDs	39	6.1 (4.2–8.0)	3.2 (2.1–4.3)	2.9 (2.0–3.8)
LITHE	Genant-modified Sharp score	52 W	TCZ (4 mg/kg) + MTX	81****	0.34****	0.21*	0.13*
			TCZ (8 mg/kg) + MTX	84****	0.29****	0.17****	0.12**
			MTX	67	1.13	0.71	0.42

*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

TSS: total Sharp score; CI: confidence interval; TCZ: tocilizumab; DMARDs: disease-modifying antirheumatic drugs; JSN: joint space narrowing; MTX: methotrexate.