Table 1.

Effect of antioxidants on liver PROTO IX levels.

Gris	PROTO IX levels (ng/mg protein)
	Control	Tx	Asc	TX + Asc	Mel	EA	Que	CA	CfA	GA	FA
Without	0.42 ± 0.04	0.45 ± 0.06	0.41 ± 0.05	0.43 ± 0.04	0.44 ± 0.03	0.45 ± 0.01	0.41 ± 0.03	0.44 ± 0.03	0.47 ± 0.05	0.36 ± 0.04	0.48 ± 0.03
With	20.32 ± 3.15**	19.85 ±2.28∗∗††	21.01 ± 3.51∗∗††	20.40 ± 3.24∗∗††	17.88 ± 3.78∗∗††	22.63 ± 4.21∗∗††	18.62 ± 3.84∗∗††	19.76 ± 4.02∗∗††	24.16 ± 5.20∗∗††	19.57 ± 3.65∗∗††	21.96 ± 3.98∗∗††

Mice received standard diet containing Gris (0.5%, w/w); in the drinking water, they also received Tx (2 mg/100 mL), Asc (12 mg/100 mL), Tx (2 mg/100 mL) plus Asc (12 mg/100 mL), ellagic acid (EA, 300 mg/L), Que (50 mg/L), CA (50 mg/L), CfA (650 mg/L), GA (50 mg/L), FA (60 mg/L), or Mel (5 mg/kg ip, 72, 48, 24 or 1 hour before sacrifice), over 14 days. Control group received only standard diet of oil (vehicle used for solubilised Gris). Data represent mean values ± SD of 6 mice. **P < 0.01: significant difference between the group treated with Gris alone or Gris plus antioxidant and the control group. ^†† P < 0.01: significant difference between the group treated with Gris plus antioxidant and the group only treated with antioxidant. Other experimental details are described in Section 2.