Table 5.
Significant differences in quality of life (QoL)
| Study | EORTC quality-of-life core questionnaire (QLQ-C30) and the EORTC Prostate Cancer Module |
|---|---|
| Crook 2012 [9,10](CIC-CTG PR.7 Trial) |
Intermittent (better):
hot flashes, desire for sexual activity, and urinary symptoms |
|
Continuous: -
| |
| Calais da Silva 2009/2011 [44,45](SEUG Trial) |
Intermittent (better):
sexual function |
|
Continuous (better):
emotional domain, nausea and vomiting, severity of insomnia | |
| Hussain 2013 [8,55](SWOG 9346 Trial) |
Intermittent (better):
erectile function and mental health at 3 months but not thereafter |
|
Continuous:
- | |
| Salonen 2012/2013 [11,12](FinnProstate Trial VII) |
Intermittent (better):
sexual function |
|
Continuous:
- | |
| Tunn 2012 [1,46,47](EC507 Trial) |
Intermittent:
NR |
|
Continuous:
NR | |
| De Leval 2002 [51] |
Intermittent:
NR |
|
Continuous:
NR | |
| Langenhuijsen 2008/2013 [52,53] (TULP Trial) |
Intermittent:
NS |
|
Continuous:
NS | |
| Miller 2007 [56] |
Intermittent (better):
sexual activity appeared to be favorable in the intermittent |
|
Continuous:
- | |
| Mottet 2012 [50](TAP 22 Trial) |
Intermittent:
NS |
|
Continuous:
NS | |
| Verhagen 2008/2013 [48,49] |
Intermittent (better):
symptom and potency scales |
|
Continuous:
- | |
| Hering 2000 [54] |
Intermittent (better):
erectile function |
|
Continuous:
- | |
| Irani 2008 [57] |
Intermittent (better):
ability to have and maintain an erection. |
|
Continuous:
- | |
| Silva 2013 [58](SEUG 9901 Trial) |
Intermittent (better):
sexual activity |
| Continuous: - |
Abbreviations: EORTC European Organization for Research and Treatment of Cancer, NS not significant, NR not reported.