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. 2014 Feb 4;9(2):e86184. doi: 10.1371/journal.pone.0086184

Figure 4. Analysis of the VH-VDJ and VK-VJ sequences to assess clonality and diversity of the recombinant rabbit antibodies.

Figure 4

The distribution of the (A) CDR-H3 length (amino acid count) and of the (B) amino acid replacement frequency within the VH region in comparison to VHa1 and VHa3 allotype germ line sequences. Dark grey: VH1a1 germ line gene; light grey: VH1a3 germ line gene. (C) Clustering of the rabbit antibodies according to their CDR-H3 and CDR-L3 sequence similarity. The bold numbers indicate the rabbits.