Table 1. MPS III Participant Information.

Sex	Age	Ethnicity	MPS III subtype	Current intervention(effectivenessa)	Previous treatmentfor sleep problems(effectivenessa)
Male	2	Pakistani	B	None	None
Male	4	White Polish	A	None	None
Male	5	White British	B	None	Behavioural advice(parents alreadyused the techniques)
Male	10	Pakistani	B	Melatoninb (good for settling),Loperamide	Herbal medicine(not effective afterthe first week)
Female	10	Pakistani	B	Walking (seems to help)Risperidone (not very helpful)	None
Female	11	White British	A	Gonapeptyl	None
Male	14	White British	A	Chloral hydrate, Zopiclone(both effective in the short-term,not long-term), Levetiracetam,Ibuprofen, Hyoscine	Melatonin (effectivein the short-term, not long-term), Behaviouralmodification (not effective)
Female	15	White British	A	Zopiclone, Clonazepam,Midazolam, Sodium Valproate,Senokot, Movicol, Omeprazole,Glycopyrrolate, Morphine, Paracetamol	Melatonin (no effect),Temazepam (effectiveinitially but became tearful & distressed)

^aEffectiveness of treatment as evaluated by parents.

^bMelatonin was withdrawn for the study.