Table 5.
Expression of ER, PR, HER 2 and EGFR by biomarkers whose expression significantly differed between subtypes
| |
ER |
P |
PR |
P |
HER2 |
P |
EGFR |
P | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Biomarkers |
Positive (%) |
Negative (%) |
Positive (%) | Negative (%) |
Positive (%) |
Negative (%) |
Positive (%) |
Negative (%) |
||||
|
PTEN |
0.76 |
|
|
0.10 |
|
|
<0.01 |
|
|
0.80 |
||
| Reduced |
163 (50.3) |
71 (52.2) |
134 (47.7) |
100 (55.9) |
34 (34.3) |
200 (55.4) |
39 (52.7) |
195 (50.9) |
||||
| Normal |
161 (49.7) |
65 (47.8) |
147 (52.3) |
79 (44.1) |
65 (65.7) |
161 (44.6) |
35 (47.3) |
188 (49.1) |
||||
|
Bcl-2 |
<0.01 |
|
|
<0.01 |
|
|
<0.01 |
|
|
<0.01 |
||
| Positive |
268 (82.0) |
35 (25.7) |
238 (83.2) |
65 (36.7) |
34 (34.7) |
269 (73.7) |
20 (27.4) |
279 (72.5) |
||||
| Negative |
59 (18.0) |
101 (74.3) |
48 (16.8) |
112 (63.3) |
64 (65.3) |
96 (26.3) |
53 (73.4) |
106 (27.5) |
||||
|
c-Kit |
|
|
<0.01 |
|
|
<0.01 |
|
|
1.00 |
|
|
<0.01 |
| Positive |
15 (4.5) |
18 (13.2) |
11 (3.8) |
22 (12.3) |
7 (7.1) |
26 (7.1) |
16 (21.6) |
16 (4.1) |
||||
| Negative |
315 (95.5) |
118 (86.8) |
276 (96.2) |
157 (87.7) |
92 (92.9) |
341 (92.9) |
58 (78.4) |
371 (95.9) |
||||
|
c-Met |
0.42 |
|
|
0.16 |
|
|
<0.01 |
|
|
0.046 |
||
| Positive |
229 (71.3) |
99 (75.6) |
194 (70.0) |
134 (76.6) |
81 (84.4) |
247 (69.4) |
60 (82.2) |
267 (70.8) |
||||
| Negative |
92 (28.7) |
32 (24.4) |
83 (30.0) |
41 (23.4) |
15 (15.6) |
109 (30.6) |
13 (17.8) |
110 (29.2) |
||||
|
Survivin |
|
|
0.03 | |
|
0.06 | |
|
<0.01 | |
|
0.24 |
| Positive |
263 (80.0) |
120 (88.2) |
228 (79.7) |
155 (86.6) |
90 (91.8) |
293 (79.8) |
64 (87.7) |
314 (81.1) |
||||
| Negative | 66 (20.0) | 16 (11.8) | 58 (20.3) | 24 (13.4) | 8 (8.2) | 74 (20.2) | 9 (12.3) | 73 (18.9) | ||||
Fisher's exact probability test was used for statistical analysis.
ER: estrogen receptor, PR: progesterone receptor, HER2: human epidermal growth factor receptor type 2, EGFR: epidermal growth factor receptor, PTEN: phosphatase and tensin homolog deleted on chromosome 10, Bcl-2: B-cell lymphoma 2, c-Met: hepatocyte growth factor receptor.