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. 2014 Feb 4;9(2):e87536. doi: 10.1371/journal.pone.0087536

Figure 3. Osteoblast- and oxidative stress-related genes in wild type and Igf1-null mice treated or not with PTHrP.

Figure 3

Gene expression (assessed by real time PCR) of Runx2, OC, OPG, RANKL, catalase and Gadd45 in the femur of wild type (WT) and Igf1-null mice, treated or not with PTHrP (1–36) (Nt) or osteostatin (Ost). The variation coefficient of vehicle-WT (control normalized to 1) value was consistently <30% in each case. This variation was taken into consideration for statistical analysis using Kruskall-Wallis test followed by Mann-Whitney test. Values are mean ± SEM corresponding to 2 males and 4 females for PTHrP-treated mice or 3 males and 3 females for vehicle-treated mice of each genotype, respectively. *p<0.05; **p<0.01 vs vehicle-treated WT value; #p<0.05; ##p<0.01 vs vehicle-treated Igf1-null mice.