Table 2. Changes in cortical parameters in the distal femur diaphysis from wild type and Igf1-null mice, treated or untreated with PTHrP (1–36) or osteostatin.

Cortical bone	WT	WT+Nt	WT+Ost	Igf1-null	Igf1-null +Nt	Igf1-null +Ost
T.Ar. (mm2)	0.75±0.01	0.87±0.03*	0.87±0.01*	0.27±0.01*	0.31±0.03	0.24±0.01
Ct.Th. (µm)	204.5±4.3	223.8±1.4*	222.2±4.0*	130.1±6.5*	126.8±7.7	117.0±2.7
J (mm4)	0.26±0.01	0.32±0.02*	0.34±0.01*	0.03±0.01*	0.05±0.01	0.03±0.01

T.Ar, total area; Ct.Th, cortical thickness; J, polar moment of inertia. Nt, PTHrP (1–36); Ost, osteostatin. Values are mean±SEM corresponding to 2 males and 4 females for PTHrP-treated mice or 3 males and 3 females for vehicle-treated mice of each genotype, respectively. Kruskall-Wallis was used to compare differences among all groups, and Mann-Whitney test for comparison between 2 groups. *p<0.05 vs vehicle-treated wild type (WT).