Table 2. V2 sequences in V1V2-scaffold antigens tested with case-control specimens*.
V1V2-scafffold Antigens | V2 Sequences |
gp70.B(CaseA2)-V1V2.APorig | CSFNITTSIRDKVQKEYALFYK LDIVPI.DNPKNST.N.YRLISC |
gp70.B(CaseA2)-V1V2.LL | CSFNITTSIRDKVQKEYALFYK LDIVPI.DNPKNST.N.YRLISC |
gp70.C(97ZA012)-V1V2 | CSFNTTTEIRDKKQQGYALFYR PDIVLLKENRNNSNNSEYILINC |
gp70.AE(92TH023)-V1V2 ‡ | CSFNMTTELRDKKQKVHALFYK LDIVPIEDNTSSS.E.YRLINC |
tags.C.(1086)-V1V2 | CSFKATTELKDKKHKVHALFYK LDVVPL.NGNSSSSGE.YRLINC |
gp70.A(92RW020)-V1V2 | CSFNITTELKDKKQQVYSLFYK LDVVQINEKNET.D.K.YRLINC |
Sequence of V2 residues present in the designated V1V2-scaffold antigens. Residues in bold indicate the V2 epitope recognized by RV144 vaccinees’ plasma as mapped with peptides [4]. Underlined residues represent the putative α4β7 binding site.
Sequence of V1V2 in ALVAC-HIV subtype E gp120 priming immunogen.