Table 3. Voxel-based morphometry results showing regions of significant grey matter intensity decrease that covary with composite scores within the bvFTD group.
MNI Coordinates | ||||||
Regions | Hemisphere (L/R/B) | X | Y | Z | Numberof voxels | T-score(peak voxel) |
Recall | ||||||
Parahippocampal gyrus/hippocampus | L | −24 | −20 | −34 | 1068 | 3.23 |
Parahippocampal gyrus/hippocampus | R | 22 | −20 | −32 | 813 | 3.23 |
Temporal pole | L | −48 | 18 | −44 | 80 | 3.23 |
Paracingulate gyrus | R | 6 | 24 | 34 | 53 | 3.23 |
Frontal pole | R | 8 | 42 | −28 | 48 | 3.23 |
Orbitofrontal cortex | L | −32 | 22 | −26 | 38 | 3.23 |
Paracingulate gyrus | R | 18 | 50 | 4 | 31 | 3.23 |
Frontal pole | R | 42 | 60 | 6 | 29 | 3.23 |
Superior frontal gyrus | L | −22 | 8 | 72 | 27 | 3.23 |
Middle frontal gyrus | R | 32 | 30 | 22 | 24 | 3.23 |
Frontal pole/Orbitofrontal cortex | L | −28 | 36 | −24 | 24 | 3.23 |
DLPFC tasks | ||||||
Precentral gyrus/Supplementary cortex | R | 6 | −14 | 58 | 502 | 3.23 |
Precentral gyrus/Postcentral gyrus | L | −48 | −10 | 28 | 108 | 3.23 |
Middle frontal gyrus | R | 34 | 8 | 58 | 69 | 3.23 |
Precentral gyrus | R | 16 | −28 | 40 | 43 | 2.93 |
Middle frontal gyrus | L | −34 | 14 | 62 | 33 | 2.93 |
Frontal pole/Middle frontal gyrus | L | −28 | 38 | 30 | 31 | 3.23 |
Precentral gyrus/Superior frontal gyrus | L | −20 | −14 | 56 | 29 | 3.23 |
Precentral gyrus | L | −45 | −10 | 32 | 28 | 2.52 |
Precentral gyrus/Middle frontal gyrus | R | 34 | −6 | 52 | 27 | 3.23 |
Precentral gyrus | L | −57 | 4 | 38 | 25 | 2.75 |
Precentral gyrus | R | 62 | 6 | 32 | 23 | 2.52 |
Superior frontal gyrus | R | 12 | 4 | 72 | 22 | 2.75 |
Cingulate gyrus (posterior) | L | −14 | −32 | 40 | 21 | 2.93 |
VMPFC tasks | ||||||
Orbitofrontal cortex/Medial prefrontal cortex/Frontal pole | B | 12 | 24 | −26 | 5589 | 3.23 |
Frontal pole | R | 8 | 46 | 46 | 96 | 3.23 |
Anterior cingulate gyrus | R | 10 | 24 | 28 | 86 | 2.93 |
Paracingulate gyrus | B | 2 | 32 | 44 | 69 | 3.23 |
Frontal pole | R | 24 | 46 | 38 | 62 | 2.75 |
Frontal pole | L | −52 | 42 | 12 | 57 | 3.23 |
Frontal pole | L | −38 | 44 | 36 | 46 | 3.23 |
Frontal pole/Superior frontal gyrus | L | −24 | 38 | 48 | 40 | 2.3 |
Frontal operculum cortex/Orbitofrontal cortex | L | −34 | 26 | 2 | 33 | 2.36 |
Anterior cingulate gyrus | L | −8 | −14 | 38 | 28 | 2.93 |
Frontal pole | L | −12 | 52 | 44 | 25 | 2.52 |
Frontal pole | L | −26 | 38 | 28 | 24 | 2.3 |
Frontal pole | L | −18 | 64 | 26 | 22 | 2.3 |
Orbitofrontal cortex | R | 26 | 24 | −26 | 21 | 2.1 |
Results FDR corrected at p<.05; only clusters with at least 20 contiguous voxels included.