Table 4. Voxel-based morphometry results showing regions of significant grey matter intensity decrease that covary with composite scores within the AD group.
MNI Coordinates | ||||||
Regions | Hemisphere (L/R/B) | X | Y | Z | Numberof voxels | T-score(peak voxel) |
Recall | ||||||
Precentral gyrus | L | −42 | −14 | 46 | 559 | 3.11 |
Precentral gyrus/postcentral gyrus | R | 40 | −24 | 58 | 182 | 3.11 |
Middle temporal gyrus (temporo-occipital part) | R | 66 | −58 | 6 | 120 | 3.11 |
Supplementary motor cortex | B | 2 | 0 | 54 | 116 | 3.11 |
Middle temporal gyrus (posterior) | R | 70 | −6 | −26 | 108 | 3.11 |
Superior frontal gyrus | R | 22 | −2 | 52 | 89 | 3.11 |
Temporal pole | R | 48 | 8 | −52 | 69 | 3.11 |
Postcentral gyrus | L | −64 | −20 | 38 | 52 | 3.11 |
Frontal pole | L | −10 | 76 | 12 | 44 | 3.11 |
Frontal pole | R | 60 | 42 | −2 | 44 | 3.11 |
Middle frontal gyrus | L | −52 | 22 | 30 | 42 | 3.11 |
Frontal pole | R | 44 | 60 | −18 | 35 | 3.11 |
Frontal pole | L | −16 | 62 | 38 | 33 | 3.11 |
Middle frontal gyrus | R | 32 | 24 | 26 | 33 | 3.11 |
Supramarginal gyrus/Middle temporal gyrus (temporo-occipital part) | L | −52 | −50 | 12 | 32 | 3.11 |
DLPFC tasks | ||||||
Precentral gyrus/Superior frontal gyrus | L | −24 | −28 | 52 | 480 | 3.11 |
Middle frontal gyrus | L | −28 | 24 | 38 | 113 | 2.83 |
Precentral gyrus | R | 12 | −16 | 72 | 27 | 2.55 |
Precentral gyrus | R | 22 | −16 | 64 | 26 | 2.83 |
Superior frontal gyrus | L | −18 | −6 | 56 | 26 | 2.67 |
Inferior frontal gyrus | L | −32 | 14 | 26 | 23 | 3.11 |
VMPFC tasks | ||||||
Orbitofrontal cortex/Frontal pole | L | −24 | 22 | −26 | 2130 | 3.11 |
Orbitofrontal cortex/Frontal pole | R | 24 | 20 | −26 | 2101 | 3.11 |
Paracingulate gyrus/Cingulate gyrus | B | −12 | 50 | 18 | 621 | 3.11 |
Frontal pole | R | 12 | 62 | 22 | 124 | 3.11 |
Frontal pole | R | 38 | 56 | 10 | 63 | 3.11 |
Paracingulate gyrus | R | 12 | 48 | −4 | 51 | 2.55 |
Frontal pole | L | −22 | 68 | −2 | 47 | 2.67 |
Supplementary motor cortex | R | 10 | 2 | 46 | 41 | 2.83 |
Frontal pole | L | −4 | 70 | 2 | 31 | 2.67 |
Paracingulate gyrus | R | 12 | 16 | 44 | 26 | 2.67 |
Results FDR corrected at p<.05; only clusters with at least 20 contiguous voxels included.