Table 1. Fine mapping of the Ity3 interval using 12 sub-congenic strains.
Table 1: | |||||||||||||||
SNP's | Position | Ity | Ity3 | B | C | D | E | F | G | I | S | A | M | N | P |
D1Mit218 | 127.4 | B6 | M | M | M | M | M | M | M | M | B6 | B6 | B6 | B6 | B6 |
rs3724826 | 131.5 | B6 | M | B6 | M | M | M | M | M | M | B6 | B6 | B6 | B6 | B6 |
D1Mit193 | 131.2 | B6 | M | B6 | M | M | M | M | M | M | B6 | B6 | B6 | B6 | B6 |
Chi3l1 | 134.1 | B6 | M | B6 | B6 | M | M | M | M | M | M | B6 | B6 | B6 | B6 |
rs6279930 | 137.3 | B6 | M | B6 | B6 | B6 | M | M | M | M | M | B6 | B6 | B6 | B6 |
D1Mit197 | 136.3 | B6 | M | B6 | B6 | B6 | M | M | M | M | M | B6 | B6 | B6 | B6 |
rs13476141 | 140.5 | B6 | M | B6 | B6 | B6 | B6 | M | M | M | M | B6 | B6 | B6 | B6 |
D1Mit448 | 141.1 | B6 | M | B6 | B6 | B6 | B6 | M | M | M | M | B6 | B6 | B6 | B6 |
rs6382880 | 142.5 | B6 | M | B6 | B6 | B6 | B6 | M | M | M | M | B6 | B6 | B6 | B6 |
rs13476163 | 146.8 | B6 | M | B6 | B6 | B6 | B6 | M | M | M | M | M | B6 | B6 | B6 |
D1Mit194 | 147.0 | B6 | M | B6 | B6 | B6 | B6 | M | M | M | M | M | B6 | B6 | B6 |
D1Mit102 | 147.2 | B6 | M | B6 | B6 | B6 | B6 | M | M | M | M | M | B6 | B6 | B6 |
D1Mit288 | 149.3 | B6 | M | B6 | B6 | B6 | B6 | M | M | M | M | M | M | B6 | B6 |
rs6393307 | 151.0 | B6 | M | B6 | B6 | B6 | B6 | M | M | M | M | M | M | B6 | B6 |
Ncf2 | 152.8 | B6 | M | B6 | B6 | B6 | B6 | B6 | M | M | M | M | M | B6 | B6 |
D1Mit14 | 156.8 | B6 | M | B6 | B6 | B6 | B6 | B6 | M | M | M | M | M | M | B6 |
rs3719034 | 157.2 | B6 | M | B6 | B6 | B6 | B6 | B6 | M | M | M | M | M | M | B6 |
rs6387609 | 157.9 | B6 | M | B6 | B6 | B6 | B6 | B6 | M | M | M | M | M | M | B6 |
rs3693161 | 160.3 | B6 | M | B6 | B6 | B6 | B6 | B6 | B6 | M | M | M | M | M | B6 |
Fasl | 161.8 | B6 | M | B6 | B6 | B6 | B6 | B6 | B6 | M | M | M | M | M | B6 |
rs13476208 | 162.0 | B6 | M | B6 | B6 | B6 | B6 | B6 | B6 | M | M | M | M | M | B6 |
Sell | 164.1 | B6 | M | B6 | B6 | B6 | B6 | B6 | B6 | M | M | M | M | M | B6 |
Selp | 164.1 | B6 | M | B6 | B6 | B6 | B6 | B6 | B6 | M | M | M | M | M | B6 |
D1Mit63 | 165.3 | B6 | M | B6 | B6 | B6 | B6 | B6 | B6 | M | M | M | M | M | B6 |
rs13476219 | 166.2 | B6 | M | B6 | B6 | B6 | B6 | B6 | B6 | M | M | M | M | M | B6 |
D1Mit403 | 175.6 | B6 | M | B6 | B6 | B6 | B6 | B6 | B6 | B6 | M | M | M | M | B6 |
rs13476273 | 182.1 | B6 | M | B6 | B6 | B6 | B6 | B6 | B6 | B6 | M | M | M | M | B6 |
rs3667164 | 188.7 | B6 | M | B6 | B6 | B6 | B6 | B6 | B6 | B6 | M | B6 | M | M | M |
D1Mit17 | 189.6 | B6 | M | B6 | B6 | B6 | B6 | B6 | B6 | B6 | M | B6 | M | M | M |
Survival | Ity | Ity | Ity | Ity | Ity | INT | Ity3 | Ity3 | Ity3 | Ity3 | INT | Ity | |||
n = | 82 | 39 | 32 | 20 | 11 | 23 | 64 | 45 | 30 | 21 | 36 | 65 | 65 | 14 |
Position (Mb) based on Ensembl Build 37;
B6 corresponds to the C57BL/6J allele;
M corresponds to the MOLF/Ei allele;
n represents the number of mice tested;
the sub-congenic strains nomenclature is shortened showing only the letter attributed to each strain.
The survival was classified, as either Ity-like (Ity) or Ity3-like (Ity3) or intermediate (INT).