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. 2014 Feb 4;9(2):e88256. doi: 10.1371/journal.pone.0088256

Figure 1. Distribution of repressive chromatin modifications on metaphase chromosomes from vole undifferentiated TS cells.

Figure 1

(A) Immunostaining (H3K9me3, green) combined with RNA FISH (Xist RNA, red); (B) H3K9me3 (red) and uH2A (green); (C) H3K9me3 (red) and HP1 (green); (D) Immunostaining (H4K20me3, green) combined with DNA FISH (MS4 repeat, red); (E) An example of repressive chromatin modification localization in the heterochromatic block of the active X-chromosome, H3K9me3 (red); (D) An example of repressive chromatin modification distribution in XEN cells. H3K27me3 (red) and H3K9me3 (green). Metaphase spreads were counterstained with DAPI (blue). Active (Xa) and inactive (Xi) X-chromosomes are indicated by arrows.