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Comparison of CR hormones (mean ± SEM) including epinephrine, norepinephrine, glucagon, and cortisol during morning hypoglycemia on days 1 and 5 of the study. In protocol 1, there was no significant blunting of CR hormones on day 5 as compared with day 1. In protocol 2, epinephrine and cortisol were significantly blunted, whereas norepinephrine and glucagon were not significantly reduced on day 5 compared with day 1. *, P < .05; **, P < .01.
