Table 2.
Cox Proportional Hazard Regression for Association of Patient and Tumor Characteristics with Overall Survival in Patients with MTC (n = 2467)
| Characteristics | n (%) | Deceased n (%) | Unadjusted HR (95% CI) | Adjusted HR (95% CI) |
|---|---|---|---|---|
| Patient characteristics | ||||
| Sex | ||||
| Male | 1007 (40.8) | 320 (31.8) | 1.00 | 1.00 |
| Female | 1460 (59.2) | 278 (19.0) | 0.55 (0.47, 0.64) | 0.81 (0.68, 0.97) |
| Age, y | ||||
| < 30 | 173 (7.0) | 18 (10.4) | 1.00 | 1.00 |
| 31–64 | 1607 (65.1) | 265 (16.5) | 1.53 (0.95, 2.47) | 1.59 (0.98, 2.58) |
| > 65 | 687 (27.9) | 315 (45.9) | 5.32 (3.31, 8.55) | 5.69 (3.34, 9.72) |
| Race | ||||
| White | 2148 (87.1) | 541 (25.2) | 1.00 | 1.00 |
| Black | 194 (7.9) | 43 (22.2) | 0.90 (0.66, 1.22) | 1.07 (0.77, 1.48) |
| Other | 125 (5.0) | 14 (11.2) | 0.45 (0.26, 0.76) | 0.69 (0.41, 1.19) |
| Insurance | ||||
| Private/Government | 1644 (66.6) | 271 (16.5) | 1.00 | 1.00 |
| Medicare | 647 (26.2) | 280 (43.3) | 3.17 (2.68, 3.75) | 1.03 (0.79, 1.36) |
| Medicaid | 96 (4.0) | 23 (24.0) | 1.58 (1.03, 2.42) | 1.57 (1.01, 2.44) |
| Uninsured | 80 (3.2) | 24 (30.0) | 2.38 (1.57, 3.61) | 1.58 (1.02, 2.44) |
| Education level less than high school diploma, % | ||||
| 29 + | 386 (15.7) | 93 (24.1) | 1.28 (1.00, 1.63) | 0.98 (0.75, 1.27) |
| 20–28.9 | 550 (22.3) | 145 (26.4) | 1.34 (1.08, 1.65) | 1.13 (0.91, 1.42) |
| 14–19.9 | 576 (23.3) | 158 (27.4) | 1.37 (1.11, 1.69) | 1.23 (0.99, 1.52) |
| <14 | 955 38.7) | 202 (21.2) | 1.00 | 1.00 |
| Rural-urban continuum | ||||
| Metropolitan population | 2053 (83.2) | 480 (23.4) | 1.00 | 1.00 |
| Other | 414 (16.8) | 118 (28.5) | 1.06 (1.02, 1.10) | 1.04 (0.99, 1.08) |
| Tumor characteristics | ||||
| Size, cm | ||||
| <1 | 492 (19.9) | 58 (11.8) | 1.00 | 1.00 |
| 1.1–2.0 | 621 (25.2) | 93 (15.0) | 1.17 (0.84, 1.62) | 1.21 (0.87, 1.68) |
| 2.1–4.0 | 899 (36.5) | 234 (26.0) | 2.17 (1.63, 2.89) | 1.88 (1.40, 2.52) |
| >4.0 | 455 (18.4) | 213 (46.8) | 4.68 (3.50, 6.26) | 2.89 (2.14, 3.90) |
| Regional lymph nodes | ||||
| Negative | 689 (27.9) | 66 (9.6) | 1.00 | 1.00 |
| Not resected | 823 (33.4) | 200 (24.3) | 2.82 (2.14, 3.73) | 2.07 (1.56, 2.75) |
| Positive | ||||
| 1–5 | 425 (17.2) | 110 (25.9) | 2.71 (2.00, 3.68) | 1.90 (1.40, 2.59) |
| 6–10 | 189 (7.7) | 73 (38.6) | 4.45 (3.19, 6.21) | 2.77 (1.96, 3.93) |
| 11–15 | 111 (4.5) | 35 (31.5) | 3.37 (2.24, 5.08) | 2.24 (1.46, 3.43) |
| >16 | 175 (7.1) | 79 (45.1) | 5.58 (4.03, 7.74) | 3.40 (2.41, 4.79) |
| No. unknown | 55 (2.2) | 35 (63.6) | 10.06 (6.67, 15.16) | 5.35 (3.50, 8.16) |
| Distant metastases | ||||
| Yes | 180 (7.3) | 140 (77.8) | 8.71 (7.18, 10.56) | 5.68 (4.61, 6.99) |
| No | 2287 (92.7) | 458 (20.0) | 1.00 | 1.00 |