Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Differentially Methylated CpG Loci by Histological Subtype and Driver Mutation
| Comparisona | Hypermethylated Loci | Hypomethylated Loci | Total Significant Loci |
|---|---|---|---|
| Follicular variant PTC | 164 | 405 | 569 |
| Classic PTC | 255 | 2582 | 2837 |
| Recurrent classic PTC | 1023 | 2796 | 3819 |
| BRAF mutant | 464 | 3604 | 4068 |
| RAS mutant | 4008 | 3884 | 7892 |
| RET/PTC rearrangement | 263 | 710 | 973 |
| All mutants (BRAF, RAS, and RET/PTC) | 368 | 2635 | 3003 |
| WT classical PTC | 154 | 672 | 826 |
Comparison with normal thyroid tissue.
