Table 3.

Genes Differentially Methylated in PTC and Pathway Analysis Results: Diseases and Disorders Associated With Differentially Methylated Genes

All PTCsa		Mutant (BRAF, RAS, and RET/PTC) Onlyb
Disease	P Value	Disease	P Value
Cancer	1.43 × 10−18	Cancer	1.19 × 10−12
Cardiovascular	1.27 × 10−14	Inflammation	1.49 × 10−9
Respiratory	1.55 × 10−12	Cardiovascular	4.78 × 10−9

^aAll classic PTC samples were compared with normal thyroid.

^bAll samples with BRAF and RAS mutations (and RET/PTC rearrangements) were compared with normal thyroid.