Table 2.

Mean Change (β-Coefficient and 95% CI) in Serum Homocysteine (Micromoles per Liter) per 10 ng/mL Rise in 25(OH)D Concentration

	Linear Regression	Linear Regression With Spline [25(OH)D ≤ 21 ng/mL]	Linear Regression With Spline [25(OH)D > 21 ng/mL]
Univariable	−0.25 (−0.34, −0.02)	−0.56 (−0.75, −0.37)	−0.09 (−0.21, 0.02)
Multivariable	−0.13 (−0.18, −0.01)	−0.49 (−0.67, −0.31)	0.02 (−0.08, 0.11)

Multivariable models were adjusted for race, gender, hypertension, smoking status, CRP, BMI, total cholesterol, renal function, glucose, serum folate, and vitamin B12.