Table 2.
Patient Clinical Characteristics and Fusion Transcripts Status
| NGS Sample ID | Age at Surgery/Gender | TNM | Histology | Tumor-Adjacent Lymphocytic Thyroiditis/Tumor-Infiltrating Lymphocytes | Fusion Transcripts |
|---|---|---|---|---|---|
| BRAF-MUT | |||||
| NGS_7 | 41/F | T3N1aM0 | PTC | Absent/0 | |
| NGS_4 | 63/F | T1bN1aM0 | PTC | Absent/0 | RHOBTB2 → PEBP4 |
| NGS_1 | 81/F | T3N1bM0 | PTC | Absent/0 | |
| NGS_16 | 39/M | T2N1aM0 | PTC | Absent/0 | |
| NGS_11 | 79/M | T1bN0M0 | PTC | Absent/0 | KIAA1267 → ARL17B |
| METTL10 → FAM53B | |||||
| PPIP5K1 → CATSPER2 | |||||
| NGS_14 | 51/M | T1bN1aM0 | PTC | Mild/2+ | HEPHL1 → PANX1 |
| NGS_18 | 31/F | T3N1aM0 | PTC | Absent/0 | HEPHL1 → PANX1 |
| METTL10 → FAM53B | |||||
| MYH14 → CLU | |||||
| NGS_19 | 61/F | T1bN0M0 | PTC | Mild/1+ | KIAA1267 → ARL17B |
| PPIP5K1 → CATSPER2 | |||||
| NGS_2 | 38/F | T2N1aM0 | PTC | Moderate/2+ | KIAA1267 → ARL17B |
| NGS_3 | 67/F | T1bN0M0 | PTC | Moderate/0 | |
| NGS_9 | 57/F | T1bN0M0 | PTC | Absent/0 | HEPHL1 → PANX1 |
| NGS_5 | 35/F | T2N1aM0 | PTC | Mild/0 | |
| BRAF-WT | |||||
| NGS_12 | 35/F | T1bN0M0 | FV | Marked/2+ | HEPHL1 → PANX1 |
| NGS_17 | 41/F | T1bN0M0 | FV | Absent/0 | HEPHL1 → PANX1 |
| RHOBTB2 → PEBP4 | |||||
| CKLF → CMTM4 | |||||
| NGS_6 | 55/M | T1bN0M0 | PTC | Mild/1+ | ETV6 → NTRK3 |
| NGS_8 | 44/F | T1bN1aM0 | PTC | Moderate/1+ | |
| NGS_10 | 38/M | T2N0M0 | PTC | Absent/0 | |
| NGS_13 | 33/F | T3N1bM0 | PTC | Mild/1 | PPIP5K1 → CATSPER2 |
| ZNF252 → TMED10 | |||||
| MKRN1 → BRAF | |||||
| NGS_15 | 43/M | T2N0M0 | PTC | Mild/0 | PPIP5K1 → CATSPER2 |
| NGS_20 | 34/F | T1bN0M0 | PTC | Mild/1+ | TG → EEF1A1 |
Abbreviations: FV, follicular variant of PTC; NCS, Next Generation Sequencing. NGS numbers were assigned to each sample, as described in the text. Fusion transcripts are described in the text. Grading scales for tumor-adjacent and tumor-invading lymphocytes are given in Materials and Methods.