Table 1.
Studies in normal neonates and infants documenting brain pHi using 31P MRS (based on [36, 38, 151–156])
| Reference | n | GA at birth (weeks) | Age when studies | Mean brain pHi | Localization |
|---|---|---|---|---|---|
| Hope et al. [36] | 6 | Median 40 (28–40) | Mean 76 h (16 h–97 days) | 7.14 ± 0.10 | Surface coil |
| Hamilton et al. [151] | 18 | Median 32 (28–42) | 5 (1–61) days GA + PNA median 35 weeks (28–42) | 6.98 ± 0.34 (28 weeks) | Surface coil |
| Boesch et al. [152] | 12 | ? | GA + PNA median 43 weeks (33 weeks–6 years) | 7.08 (SD 0.1) | Surface coil |
| 8 were studied at 40 weeks | |||||
| Azzopardi et al. [153] | 30 (data from 23) | Median 33 (24–42) | GA + PNA median 34 weeks (26–42) | 7.1—no change with maturation | Surface coil |
| AGA 28 weeks 7.14 (±0.28) | |||||
| 42 weeks 7.09 (±0.28) | |||||
| SGA 28 weeks 6.97 (±0.24) | |||||
| 42 weeks 7.19 (±0.24) | |||||
| Laptook et al. 1989 [154] | 7 | 40±1 | 10 examinations within the first 2 weeks after birth | 7.02 ± 0.08 | Surface coil |
| Van der Knapp et al. [155] | 41 | Term | Mean 71 months (1 months–16 years) | 7.04 (95 % CI 6.96–7.12) | Volume localized (ISIS) |
| No significant change | |||||
| Buchli et al. [156] | 16a | Term | 2–28 days GA + PNA mean 42 weeks (39–44) | 7.11 (±0.06) | Volume localized (ISIS) |
| Martin et al. [38] | 10a | Median 40 (36.3–42.1) | Median 4.3 days | 7.12 (±0.05) | Volume localized (ISIS) |
| Robertson et al., unpublished data | 3 | Median 39 (38–40) | GA + PNA median 44 weeks (41–64) | 7.02 (±0.03) | Volume localized (ISIS) |
GA gestational age, PNA postnatal age
aControls were healthy term newborn babies who had been hospitalised for non-neurologic reasons