Table 1.
Clinical characteristics of patients at the time of initiating regional citrate anticoagulation- and heparin-anticoagulation renal replacement therapy
| Clinical characteristics | RCA-CRRT | HA-CRRT | p |
|---|---|---|---|
| No. of patients | 16 | 14 | na |
| Gender (n) | 7 females/9 males | 8f/6m | na |
| Disease categories (n) | CS (11)/S (3)/NS (2) | CS (7)/LEU (3)/MODS (2) | na |
| Age (months) | 15.25 ± 24.10 | 24.15 ± 27.96 | 0.523 |
| Weight (kg) | 7.76 ± 4.67 | 9.77 ± 6.21 | 0.355 |
| Mean arterial pressure (mmHg) | 72 ± 27.59 | 66 ± 12.86 | 0.938 |
| Edema (%) | 100 | 85 | na |
| Mechanical ventilation (%) | 75 | 86 | na |
| Total parenteral nutrition (%) | 75 | 93 | na |
| Multiorgan dysfunction syndrome (MODS) (%) | 75 | 93 | na |
| Creatinine (mg/dl) | 1.04 ± 0.66 | 0.93 ± 0.79 | 0.294 |
| Blood urea nitrogen (mg/dl) | 103.56 ± 70.61 | 96.64 ± 62.72 | 0.822 |
| Aspartate aminotransferase (IU/l) | 1828.67 ± 3230.12 | 592.64 ± 1096.29 | 0.354 |
| Acute liver failure (n) | 8 (50 %) | 6 (43 %) | na |
| Systemic sodium (mmol/l) | 144.82 ± 8.67 | 142.06 ± 8.89 | 0.377 |
| Systemic ionized Ca (mmol/l) | 1.11 ± 0.18 | 1.10 ± 0.17 | 0.892 |
| Systemic lactate (mmol/l) | 6.44 ± 4.82 | 5.15 ± 5.35 | 0.492 |
| pH (units) | 7.39 ± 0.13 | 7.41 ± 0.08 | 0.983 |
| HCO3 (mmol/l) | 21.46 ± 5.54 | 25.02 ± 6.14 | 0.387 |
| Base excess (units) | −3.68 ± 6.85 | 0.28 ± 6.75 | 0.467 |
| Activated partial thromboplastin time (s) | 44.47 ± 16.69 | 55.09 ± 68.36 | 0.224 |
RCA, Regional citrate anticoagulation; HA, heparin anticoagulation; CRRT, continuous renal replacement therapy; CS, after cardiac surgery; S, sepsis; NS, nephrotic syndrome; LEU, leukemia; na, non-applicable
Unless indicated otherwise, data are presented as the mean ± standard deviation (SD)