Fig. 1.

Plasma concentration profiles of regorafenib and its metabolites M2 (N-oxide metabolite) and M5 (N-oxide/N-desmethyl metabolite). a After a single oral dose of regorafenib 160 mg in Cycle 0. b After 21 days of dosing with regorafenib 160 mg once daily during Cycle 1. Data are geometric means, calculated from before the regorafenib dose during single dosing in Cycle 0 (time 0; n = 15) and before the regorafenib dose on day 21 of Cycle 1 (time 0; n = 11 for the pre-dose measurement, n = 12 for all other timepoints)