Table 3.
Details of drug-related treatment-emergent adverse events resulting in treatment reduction or interruption
| Patient | Primary tumor | Adverse event | Cycle | Dose change | Grade | Outcome |
|---|---|---|---|---|---|---|
| 1 | Pancreatic cancer | Leukopenia | 1 | Interrupted | 2 | Resolved |
| Thrombocytopenia | 1 | Interrupted | 2 | Resolved | ||
| AST elevation | 1 | Interrupted | 3 | – | ||
| ALT elevation | 1 | Interrupted | 3 | – | ||
| AST elevation | 2 | Reduced | 4 | Unchanged | ||
| ALT elevation | 2 | Reduced | 4 | Unchanged | ||
| 2 | Carcinoid tumor | Diarrhea | 3 | Reduced | 3 | Resolved |
| Hand–foot skin reaction | 7 | Interrupted | 3 | Unchanged | ||
| 3 | Submandibular gland neoplasm | Dental pulpitis | 3 | Interrupted | 2 | Resolved |
| 4 | Pancreatic cancer | Hand–foot skin reaction | 3 | Reduced | 1 | – |
| 9 | Reduced | 1 | Resolved | |||
| Back pain | 11 | Interrupted | 3 | Resolved | ||
| Back pain | 12 | Reduced | – | – | ||
| 5 | Pancreatic cancer | Hypertension | 1 | Interrupted and reduced | 2 | Resolved |
| Hand–foot skin reaction | 2 | Interrupted | 3 | – | ||
| 3 | Reduced | 1 | Resolved | |||
| 6 | Carcinoid tumor | Proteinuria | 9 | Interrupted | 3 | – |
| Proteinuria | 10 | Reduced | 2 | Resolved | ||
| Gingivitis | 18 | Interrupted | 2 | Resolved | ||
| 7 | Gastric cancer | AST elevation | 2 | Interrupted | 3 | Resolved |
| 8 | Small-intestine carcinoma | Neutropenia | 1 | Interrupted and reduced | 3 | Resolved |
AST aspartate aminotransferase, ALT alanine aminotransferase