Table 4. Overview of detected mutations in AML blasts and response outcome.
Gene | Mutation | Responders (CR/PR) (%) |
---|---|---|
KRAS | G12D/V/A, G13D/A | 3/6 (50) |
NRAS | G13D/V/A, Q61H | 0/2 (0) |
NPM1 | W288C | 0/4 (0) |
IDH2 | R140L/G | 1/3 (33) |
JAK2 | V617F | 2/2 (100) |
MPL-2 | W515L/X | 0/2 (0) |
DNMT3a | R882C/H | 0/2 (0) |
FLT3 | ITD | 0/1 (0) |