Table 4.
Endpoint 2 – death, aborted SCD, appropriate ICD discharge or hospitalization for heart failure
| |
Endpoint 2 |
No endpoint |
p-value |
OR (95% - CI) |
|---|---|---|---|---|
| (n = 26) | (n = 379) | |||
| Age [years] |
61.1 (51.2-68.6) |
47 (36–59.5) |
<0.001 |
|
| Gender, female |
9 (34.6) |
168 (44.3) |
0.33 |
0.66 (0.29-1.53) |
| Referring physician |
|
|
|
|
| Inpatients |
21 (80.8) |
201 (53.0) |
<0.01 |
3.80 (1.40-10.28) |
| Outpatients referred by cardiologists |
5 (19.2) |
149 (39.3) |
<0.05 |
0.37 (0.14-0.99) |
| Outpatients referred by general practitioners |
0 |
29 (7.7) |
0.14 |
|
| Primary cardiac symptoms leading to CMR |
|
|
|
|
| Reduced LVEF |
15 (57.7) |
67 (17.7) |
<0.0001 |
6.35 (2.79-14.44) |
| Pericardial effusion |
0 |
6 (1.6) |
0.52 |
|
| ECG abnormality |
7 (26.9) |
124 (32.7) |
0.54 |
0.76 (0.31-1.85) |
| Palpitations |
5 (19.2) |
87 (23) |
0.66 |
0.80 (0.29-2.18) |
| Dyspnea |
18 (69.2) |
119 (31.4) |
<0.0001 |
4.92 (2.08-11.62) |
| Angina/Chest pain |
10 (38.5) |
207 (54.6) |
0.11 |
0.52 (0.23-1.17) |
| Abnormal fatigue |
4 (15.4) |
92 (24.3) |
0.30 |
0.57 (0.19-1.68) |
| Wall motion abnormality |
0 |
17 (4.5) |
0.27 |
|
| Ventricular arrythmias/Extrasystoles |
2 (7.7) |
43 (11.3) |
0.57 |
0.65 (0.15-2.85) |
| Aborted SCD |
0 |
6 (1.6) |
0.52 |
|
| Viral Prodrome/history of infectious symptoms |
4 (15.4) |
126 (33.2) |
0.06 |
0.37 (0.05-2.81) |
| Atrial fibrillation |
9 (34.6) |
41 (10.8) |
<0.001 |
4.35 (1.82-10.39) |
| Elevated troponin |
1 (3.8) |
37 (9.8) |
0.32 |
0.37 (0.05-2.81) |
| EMB performed |
16 (64) |
62 (17.5) |
<0.0001 |
8.40 (3.55-19.88) |
| Histological myocarditis in EMB |
10 (62.5) |
43 (70.5) |
0.54 |
0.70 (0.22-2.21) |
| CMR imaging parameters |
|
|
|
|
| LVEF [%] |
39 (22.0-59.0) |
63 (57.0-69.0) |
<0.0001 |
|
| LV-EDV [ml] |
181 (126.0-284.0) |
136 (108.0-162.0) |
<0.001 |
|
| LV-ESV [ml] |
123 (52.0-188.0) |
49 (36.0-67.0) |
<0.0001 |
|
| LVEDD [mm] |
58.5 (54.0-65.0) |
50 (45.0-54.0) |
<0.0001 |
|
| Pericardial effusion present |
11 (42.3) |
65 (17.2) |
<0.01 |
3.53 (1.55-8.04) |
| LGE present |
18 (69.2) |
96 (25.5) |
<0.0001 |
6.59 (2.77-15.63) |
| Final diagnosis based on CMR |
|
|
|
|
| No cardiac pathology |
1 (3.8) |
224 (59.1) |
<0.0001 |
6.59 (2.77-15.63) |
| Myocarditis |
17 (65.4) |
99 (26.1) |
<0.0001 |
5.34 (2.31-12.37) |
| Other cardiac pathology |
8 (30.8) |
55 (14.5) |
<0.05 |
2.62 (1.09-6.32) |
| Medication |
|
|
|
|
| Betablockers at follow-up |
20 (87.0) |
111 (31.8) |
<0.0001 |
14.29 (4.16-49.11) |
| ACEI/ARB at follow-up | 20 (87.0) | 87 (24.09) | <0.0001 | 20.08 (5.82-69.20) |
Values shown are n (%) or medians (25th -75th percentiles) Abbreviations are the same as in Table 1.