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. 2014 Feb 5;5:17. doi: 10.3389/fphys.2014.00017

Figure 5.

Figure 5

Decreased tumor growth and angiogenesis in mice bearing SEMA7A silenced mammary tumors. (A) Tumor volume is decreased in mice bearing SEMA7A shRNA knockdown DA-3 mammary tumor compared with either wild type or SEMA7A scramble shRNA DA-3 mammary tumors; (B) ventral image of DA-wild type, SEMA7A scramble shRNA DA-3 or SEMA7A shRNA knockdown DA-3 mammary tumor bearing mice showing 1 out 20 mice/group; quantification (photons/sec) of AngioSense specific fluorescent signal indicating decreased angiogenesis at 21 days post-tumor implantation in the SEMA7A knockdown group, N = 10 per group, repeated twice **p ≤ 0.01. (C) H&E and CD31 staining in tumor sections from DA-3 wild type, scramble shRNA and SEMA7A shRNA knockdown tumor sections. Significance is indicated *p ≥ 0.01.