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. Author manuscript; available in PMC: 2015 Jan 3.
Published in final edited form as: Angew Chem Int Ed Engl. 2013 Nov 20;53(1):199–204. doi: 10.1002/anie.201307387

Figure 3.

Figure 3

Summary of differences in deuterium exchange in K-Ras G12C bound to GMPPNP, GDP, and SML-8-73-1. Hydrogen deuterium exchange suggests that SML-8-73-1 places K-Ras G12C in the inactive state. (A) Relative deuterium uptake curves for two key peptides (top: residues 7–20, VVVGACGVGKSALT; bottom: residues 114–120, VGNKCDL) showing differences in deuterium incorporation. These are representative data: each data point is the average of duplicate mass determinations from one of three triplicates of the entire experimental measurement (see supporting information). (B) Location of the two regions from panel A, on PDB file 4Q21. GDP is shown in brown, residues 7–20 in blue, and residues 114–120 in red.

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