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Angiogram before (a) and after (b) administration of 200 micrograms IV ergonovine showing focal spasm of the left anterior descending artery (courtesy of Adlam, et al (59), reprint permission requested). Angiogram before (c) and after (d) intracoronary infusion of acetylcholine at a concentration of 0.182 micrograms/milliliter (2 milliliters over 3 minutes) showing diffuse spasm of the left anterior descending artery.
