. Author manuscript; available in PMC: 2015 Jan 21.

Published in final edited form as: J Am Coll Cardiol. 2013 Nov 6;63(2):103–109. doi: 10.1016/j.jacc.2013.10.038

Table 1.

Provocation Testing Dosing Protocols

Study	Ergot Derivative	Acetylcholine
*Invasive*
Akasaka et al (10)	ER 100 ug IV (up to 200 ug)	N/A
Bertrand et al (11)	Methergine 400 ug IV	N/A
Hackett et al (6)	ER 6–50 ug IC	N/A
Harding et al (12)	ER 50–150 ug IV	N/A
Japanese Circulation Society (45)	ER 20–60 ug (LCA, IC); ER 20–60 ug (RCA, IC)	20–100 ug (LCA, IC); 20–50ug (RCA, IC)
Okumura et al (8,22)	200 ug IV	20–100 ug (LCA, IC); 20–50 ug (RCA, IC)
Song et al (19)	ER 1–30 ug IC	10–100 ug IC
Sueda et al (13–16,23)	ER 40ug (RCA, IC); 64 ug (LCA, IC)	20–100 ug (LCA, IC); 20–80 ug (RCA, IC)
Takagi et al (18)	ER 20–60 ug (LCA, IC); ER 20–60 ug (RCA, IC)	20–100 ug (LCA, IC); 20–50 ug (RCA, IC)
Waters et al (17)	ER 12.5–400 ug IV	N/A
Yasue et al (21)	N/A	suspected vessel: 10–100 ug IC; Contralateral artery:20–100 ug (LCA, IC); 20–50 ug (RCA, IC)
*Noninvasive*
Song et al (20)	ER 25–50 ug IV (up to 350 ug total)	N/A

ER= ergonovine maleate, IC= intracoronary, IV=intravenous, LCA= left coronary artery, ml= milliliter, NSS= normal saline solution, RCA= right coronary artery, ug= micrograms, N/A= not applicable.