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Schematic diagram of GSH-based detoxification pathway. MCB is used as a model substrate for conjugation to GSH by GST in the cytosol and there is subsequent sequestration by a GSX pump. MCB is not fluorescent until conjugated to GSH giving the MCB-GSH conjugate. If another xenobiotic substrate for conjugation is present such as isofuranonaphthoquinone (Iso), competition will occur (Iso-GSH), resulting in the decrease in fluorescence signal from MCB-GSH conjugate formation.
