(a)  

	Level I VRB = 20 mg		Level II VRB 30 mg		Level III VRB 40 mg		Total
	Per Pts	Per cycle	Per pts	Per cycle	Per pts	Per cycle	Per pts	Per cycle
Events G1
Abdominal pain	0	0	2	3	5	15	7	18
Nausea	1	1	2	4	1	6	4	11
Gastric pain	0	0	1	1	3	3	4	4
Diarrhea	0	0	0	0	2	4	2	4
Vomiting	0	0	0	0	1	1	1	1
Stomatitis	0	0	1	1	1	1	2	2
Asthenia	0	0	1	1	2	2	3	3
Dyspnea	1	1	0	0	1	1	2	2
Dysgeusia	0	0	0	0	1	1	1	1
Anemia	0	0	0	0	0	2	2	2
Leukopenia	0	0	0	0	0	2	2	2
Increase in  transaminases	0	0	1	1	0	0	2	1
Total	2	2	8	11	17	38	32	51
Events G2
Abdominal pain	0	0	0	0	1	1	1	1
Nausea	0	0	1	2	2	2	3	4
Asthenia	0	0	1	2	3	4	4	6
Constipation	2	2	0	0	0	0	2	2
Total	2	2	2	4	6	7	10	13