(b)
| Per pts | Per cycle | |
|---|---|---|
| Events G1 | ||
| Abdominal pain | 3 | 14 |
| Nausea-vomiting | 8 | 20 |
| Gastric pain | 4 | 4 |
| Diarrhea | 5 | 8 |
| Stomatitis | 2 | 2 |
| Asthenia | 4 | 15 |
| Anemia | 3 | 4 |
| Neutropenia | ||
| Thrombocytopenia | ||
| Leukopenia | 4 | 11 |
| Transaminitis | ||
| Dyspnoea | 1 | 1 |
| Neuropathy | 3 | 4 |
| Hand-foot syndrome | 1 | 1 |
| Nail changes | 1 | 1 |
| Muscular pain | 3 | 5 |
| Total | 40 | 90 |
| Events G2 | ||
| Abdominal pain | 4 | 4 |
| Nausea-vomiting | 4* | 4 |
| Diarrhea | 1 | |
| Stomatitis | 1* | 1 |
| Asthenia | 8 | 10 |
| Dysgeusia | 1 | 1 |
| Neutropenia | 1 | |
| Anemia | 1 | 3 |
| Hand-foot syndrome | 1 | 2 |
| Nail changes | 2 | 2 |
| Total | 22 | 29 |
| Events G3 | ||
| Neutropenia | 1** | 2 |
| Thrombocytopenia | 1 | 1 |
| Leukopenia | ||
| Neuropathy | 1*** | 2 |
| Hand-foot syndrome | 1**** | 1 |
| Gamma GT increase | 1 | 1 |
| Total | 5 | 7 |
| Events G4∧ | ||
| Neutropenia | 1 | 1 |
| Febrile neutropenia | 1 | 1 |
| Leukopenia | 2 | 2 |
| Total | 4 | 4 |
*In 1 patient vomiting and stomatitis Grade 2 determined a dose reduction of VRB at 20 mg thrice a week.
**In 1 patient Grade 3 neutropenia was associated to Grade 1 Leukopenia; no dose reduction was required.
***Grade 3 neuropathy determined a dose reduction of VRB at 20 mg thrice a week.
****Grade 3 hand-foot syndrome determined a dose reduction of CAPE at 500 mg twice a day, until complete recovery to Grade 1.
∧See details in the text.