Fig. 1.

STC1 is upregulated in patients with AL cardiomyopathy and in response to AL-LC stimulation. a STC1 gene expression (normalized to 18S) and b STC1 protein expression relative to GAPDH were upregulated in AL cardiomyopathy patients (N=6) as compared to non-failing control patients (N=5). AL-LC triggers c STC1 gene and d, e protein expression in isolated cardiomyocytes exposed to AL-LC for 2 hour and 24 hours, respectively, relative to those exposed to Con-LC or Veh. f STC1 was upregulated early with AL-LC obtained from 5 independent patients with amyloid cardiomyopathy as compared to Veh or Con-LC. * p<0.05 between indicated groups.