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AL-LC induction of STC1 is p38MAPK dependent in vitro and in vivo. a AL-LC induced upregulation of STC1 protein expression in cardiomyocytes was abolished in the presence of p38MAPK inhibitor, SB203580 (5 μmol/L). b AL-LC triggered upregulation of cardiac STC1 protein expression was prevented in p38MAPK dominate negative (DN-TG) mice. * p<0.05, AL-LC vs. vehicle or Con-LC, # p<0.05 AL-LC with vs. without SB203580 or AL-LC infused wild type mice vs. DN-TG mice. N=3 for each group.
