Fig. 4.
STC1 induces contractile dysfunction and cell death in cardiomyocytes. Adenoviral mediated overexpression of STC1 in cardiomyocytes (Adeno-STC1) decreased a cellular contractile function (% cell shortening) and b intracellular calcium transient amplitude as well as increased cell death determined using c Bax/Bcl2 ratio and d TUNEL assay relative to control (Adeno-GFP). Representative tracing of cell shortening and calcium transient are shown in the upper panels of a and b, respectively. N=3 for each group. * p<0.05 between indicated groups