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Effects of pioglitazone on hepatic steatosis in rats fed a high-fat diet. Hepatic histopathological changes in the normal control (a) and pioglitazone control (c) groups were within normal limits. Severe hepatic steatosis was found in the high-fat diet group (b). Hepatic steatosis was significantly improved in the high-fat diet plus pioglitazone group (d). (Haematoxylin and eosin; original magnification ×10.)
