Table 1.
Data for body weight, liver weight, and biochemical parameters in the normal control (NC), high-fat diet (HFD), pioglitazone control (PC), and high-fat diet plus pioglitazone (HP) groups.
| NC group | HFD group | PC group | HP group | |
|---|---|---|---|---|
| Final body weight (g) | 449.7 ± 44.7 | 643.6 ± 127.5*** | 426.2 ± 34.9 | 584.9 ± 65.3 |
| Liver weight (g) | 14.4 ± 1.4 | 32.6 ± 8.2*** | 11.6 ± 1.5 | 22.5 ± 3.2†† |
| Liver/body weight ratio (%) | 3.2 ± 0.3 | 5.0 ± 0.4*** | 2.7 ± 0.3 | 3.9 ± 0.6††† |
| FPG (mmol/L) | 5.5 ± 0.6 | 11.8 ± 2.6*** | 7.3 ± 1.2** | 9.8 ± 1.1† |
| FINS (mIU/L) | 9.5 ± 1.4 | 21.6 ± 5.5*** | 8.0 ± 0.8 | 14.3 ± 1.9††† |
| HOMA-IR | 2.4 ± 0.6 | 11.3 ± 3.5*** | 2.6 ± 0.4 | 6.3 ± 1.2††† |
| TC (mmol/L) | 1.9 ± 0.5 | 3.1 ± 0.5*** | 1.9 ± 0.2 | 2.2 ± 0.2††† |
| HDL-C (mmol/L) | 1.3 ± 0.2 | 1.6 ± 0.2*** | 1.3 ± 0.2 | 1.2 ± 0.1††† |
| LDL-C (mmol/L) | 0.4 ± 0.1 | 1.5 ± 0.3*** | 0.5 ± 0.1 | 1.0 ± 0.2††† |
| TG (mmol/L) | 1.1 ± 0.2 | 2.3 ± 0.3*** | 0.9 ± 0.2** | 1.0 ± 0.2††† |
| FFA (mmol/L) | 0.6 ± 0.1 | 1.0 ± 0.1*** | 0.7 ± 0.2 | 0.5 ± 0.1††† |
| ALT (IU/L) | 34.3 ± 5.6 | 91.3 ± 29.1*** | 31.7 ± 8.7 | 52.1 ± 4.3††† |
| AST (IU/L) | 128.2 ± 49.6 | 153.4 ± 45.3 | 126.0 ± 29.9 | 128.9 ± 20.1 |
| ALP (IU/L) | 144.2 ± 43.7 | 243.0 ± 73.3*** | 151.0 ± 23.7 | 163.1 ± 34.4††† |
Data are presented as mean ± SD. **P < .01, ***P < .001 versus NC group. † P < .05, †† P < .01, and ††† P < .001 versus HFD group.
FPG: fasting blood glucose; FINS: fasting insulin; HOMA-IR: homeostasis model assessment of insulin resistance; TC: total cholesterol; HDL-C: high density lipoprotein-cholesterol; LDL-C: low density lipoprotein-cholesterol; TG: triglyceride; FFA: free fatty acid; ALT: alanine aminotransferase; AST: aspartate aminotransferase; ALP: alkaline phosphatase.