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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Prog Lipid Res. 2013 Dec 15;53:108–123. doi: 10.1016/j.plipres.2013.11.003

Fig. 1.

Fig. 1

The metabolism of arachidonic acid by cytochrome P450 (CYP) epoxygenases (largely CYP2C and CYP2J) leads to the formation of epoxyeicosatrienoic acids (EETs) including four regioisomers of 5,6-, 8,9-, 11,12- and 14,15-EET. EETs are further metabolized by soluble epoxide hydrolase (sEH) to form the fatty acid diols termed dihydroxyeicosatrienoic acids (DHETs) which are usually less-active or inactive.