Figure 3.

COX-deficient fibre density is dependent on skeletal muscle mitochondrial DNA heteroplasmy and deletion of MT-CO genes. The y-axis shows the square root of the COX-deficient fibre density %. Data are from our cohort, n = 72, R² = 0.43. Heteroplasmy (P < 0.0001) and deletion of MT-CO genes (P = 0.0018) are both significant predictors. Separate regression lines are shown for those that delete one or more MT-CO genes (n = 63, 95% CI for regression line shown) and those that do not (n = 9, gradient of regression line is not significantly non-zero, CI not shown).