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. 2013 Dec 5;137(2):420–432. doi: 10.1093/brain/awt327

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© The Author (2013). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Neuron-specific loss of merlin is sufficient to increase ErbB2 levels on Schwann cells. (A) Representative pictures of immunohistochemical staining of mouse sciatic nerves taken from neuron-specific merlin knockout animals (Nefh-Cre;Nf2^fl/fl) and wild-type littermates (Nefh-Cre;Nf2^+/+). Visualization of antibodies raised against NRG1 and ERBB2 with diaminobenzidine (brown), counterstained with Mayer's haemalum. Scale bar = 20 µm. (B) Quantifications of NRG1 and ERBB2-positively labelled fibres in neuron-specific merlin knockout mice (Nefh-Cre;Nf2^fl/fl) and controls (data represent mean ± SEM, **P < 0.01; n = 3). (C) Immunoblot of sciatic nerve lysates derived from homozygous (Nefh-Cre;Nf2^fl/fl) and heterozygous neuron-specific merlin knockout mice (Nefh-Cre;Nf2^fl/+) indicates elevated ERBB2 protein levels and decreased phosphorylation of Erk (pErk) compared with wild-type littermates (Nefh-Cre;Nf2^+/+; n = 3).