Figure 1.

The crotamine derived peptide NrTP1 structure. NrTP1 synthetic peptide combines the N- and C-terminus of crotamine and embraces the first nine residues that are linked to the last residues 38–42, which are depicted in black in structure of the crotamine molecule above. NrTP1 and analogues are capable of membrane translocating and they localize in the nucleolus of tumor cells. Crotamine structure contains 42 residues arranged in a topology αβ ₁ β ₂: one α-helix with residues 1–7 and two-stranded antiparallel β-sheets with residues 9–13 and 34–38. The structure is stabilized by three disulfide bridges C₄–C₃₆; C₁₁–C₃₀; C₁₈–C₃₇ [1, 2]. This figure was adapted from [5].