Ingenuity pathway analysis (IPA) reveals upregulation of cancer-related cellular networks and downregulation of cell death pathways

Function	Transcription in L-GMP	Predicted Activation	p-Value	Z-score	Molecules
Transformation	Specifically increased or newly expressed	Increased	1.42E-07	5.219	138
	Specifically decreased or shut-down	Increased	2.59E-03	5.030	115
Survival	Specifically increased or newly expressed	Increased	5.45E-05	10.778	305
	Specifically decreased or shut-down	Increased	7.17E-09	10.760	327
Proliferation	Specifically increased or newly expressed	Increased	4.01E-11	9.965	860
	Specifically decreased or shut-down	Increased	3.54E-09	6.445	834
Expression of RNA	Specifically increased or newly expressed	Increased	1.26E-09	2.976	546
	Specifically decreased or shut-down	Increased	1.74E-03	4.431	485
Cytoplasmatic Organization	Specifically increased or newly expressed	Increased	8.87E-07	5.747	331
	Specifically decreased or shut-down	Increased	6.21E-06	6.207	321
Cell Death	Specifically increased or newly expressed	Decreased	1.72E-08	−2.395	777
	Specifically decreased or shut-down	no prediction	4.50E-12	−1.031	794

Analysis of L-GMP-specific gene expression showed a significant increase of pathways associated with transformation, survival, proliferation, RNA expression and cytoplasmatic organization and a downregulation of pathways associated to cell death. Gene function, transcriptional modulation in L-GMP as compared to Ctrl-GMP, the IPA predicted functional activation status, p-values, Z-scores and the number of mapped individual molecules are indicated.