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. 2013 Oct 20;5(12):1835–1851. doi: 10.1002/emmm.201302655

Figure 6.

Decorin is overexpressed in human bladder tumours during progression and correlated with angiogenesis related-genes within MIBC

  1. Decorin (DCN) mRNA expression in our set of 162 human bladder tumours. Expression levels in individual samples, and the median (horizontal bar) of each group of samples are represented. p was calculated by Wilcoxon's rank sum test. Urothelium = normal tissue; Ta, T1 = non-muscle-invasive bladder carcinoma (NMIBC); >pT2 = muscle-invasive bladder carcinoma (MIBC).

  2. Expression of decorin (DCN) protein in a section of a high-grade invasive human tumour (upper panel, arrows indicate tumour area containing epithelial cells) and of a normal bladder (lower panel). Scale bar 100 µm. Pictures were extracted from the human protein atlas portal (http://www.proteinatlas.org/). Immunolabelling of decorin was performed using two different antibodies showing the same localization of decorin.

  3. Pathways and gene ontology biological processes significantly enriched within genes positively correlated with DCN in human MIBC. Genes correlated with DCN expression in MIBC were determined using Pearson's correlation (p < 1.10−6 and R > 0.5) (Supporting Information Table S1). Significant enrichment of genes related to physiological pathways (italics) and gene ontology annotations relative to biological process within genes positively regulated with DCN were determined by DAVID software (corrected p-value < 0.01 and corrected p-value < 0.001, respectively) (Supporting Information Tables S1 and S2). All these pathways and gene ontology annotations, except one, can be grouped into four known functions of decorin.

Figure 6

HHS Vulnerability Disclosure