Figure 3.

Dissection of genetic and nongenetic effects of evQTL using twins data. (A) The evQTL between AXIN2 and rs740026. The expression data points from pairs of MZ twins are linked. (B) Same as A except that DZ twins are linked. (C) CDFs of RMD between twins classified into four groups, namely MZ-S, DZ-S, MZ-L, and DZ-L (see main text for definitions). The double arrow highlights the highly significant discrepancy in RMD distribution between MZ-L and DZ-L (K–S test, P < 0.01). Insert shows the same CDFs of RMD recomputed after randomly shuffling identities of corresponding MZ and DZ pairs. (D) Same as C except that data are randomly sampled from non-evQTL genes.