Figure 8.
Model of MIG-17- and MIG-18-dependent regulation of DTC migration. MIG-18 acts as a cofactor to activate MIG-17. The activated MIG-17 efficiently recruits FBL-1C to the gonadal basement membrane, where it activates FBL-1C and LET-2. The activated FBL-1C recruits NID-1 to control DTC migration.