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. Author manuscript; available in PMC: 2014 Feb 5.
Published in final edited form as: Adv Drug Deliv Rev. 2012 Dec 1;64(Suppl):353–365. doi: 10.1016/j.addr.2012.09.011

Fig. 1.

Fig. 1

Quantitative understanding of various steps involved in the delivery of therapeutic agents is studied by analyzing the underlying processes and then integrating the resulting information in a unified framework. More specifically, our goal is to develop a quantitative understanding of (a) angiogenesis and blood flow; (b) metabolic microenvironment; (c) transvascular transport; (d) interstitial and lymphatic transport; (e) cell transport, and (f) systemic distribution and interspecies scale-up.