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. Author manuscript; available in PMC: 2014 Feb 5.
Published in final edited form as: Adv Drug Deliv Rev. 2012 Dec 1;64(Suppl):353–365. doi: 10.1016/j.addr.2012.09.011

Fig. 6.

Fig. 6

Spatial gradients of metabolites in tumors. (a) pH gradients measured using fluorescence ratio imaging microscopy (adapted from Ref. [54]). (b) pO2 gradients measured using phosphorescence quenching (adapted from Ref. [55]). Distance from the vessel wall, in microns, is shown on the x-axis, with zero being the vessel wall.